目的：感染嚴重特殊傳染性肺炎的病人，可能會有持續3個月之症狀，被稱為“新冠後症候群”。本研究分析病人的症狀及相關因素。
方法：回溯性病歷研究，收集從2022年1月至2023年3月間的新冠肺炎整合門診之病人，追蹤至解除隔離日起算6個月止。定義有持續3個月（≧90天）之症狀且無其他可解釋原因，為新冠後症候群。收集病人自填症狀問卷、簡式健康量表、性別、年齡、慢性病史、是否施打2劑疫苗、急性期有無住院。
結果：總共收案174人，男性78人(44.8%)，女性96人(55.2%)。新冠後症候群有69人(39.7%)，男性28人(40.6%)，女性41人(59.4%)，新冠後症候群較常出現的症狀是疲勞感、記憶減退、咳嗽、注意力不集中、頭痛、肌肉痠痛、呼吸困難。有統計顯著差異的症狀是記憶減退、無故掉髮、皮膚疹。症狀的相關因素有：性別、胃食道逆流、過敏性鼻炎、新冠感染急性期住院等。在簡式健康量表評分的項目，情緒困擾的嚴重程度與發生新冠後症候群症狀的人數有相關趨勢。
結論：新冠肺炎病毒感染會影響多器官系統，病人有各種不同的症狀。新冠後症候群病人症狀持續的時間久，有必要進行長期追蹤，以了解病理的機制以及感染的影響。
(台灣家醫誌2025; 35: 98-115) DOI: 10.53106/168232812025063502004
 
關鍵詞：嚴重特殊傳染性肺炎、新冠後症候群、新型冠狀病毒、簡式健康量表、疫苗

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臺北市立聯合醫院忠孝院區家庭醫學科
受理日期：113年7月28日 修改日期：113年9月27日 同意刊登：113年12月7日
^*通訊作者：侯君穎 通訊地址：臺北市立南港區同德路87號 E-mail：DAR12@tpech.gov.tw
 

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Symptoms and Related Factors of Patients withPost COVID-19 Condition- A Retrospective Studyon the COVID-19 Integrated Outpatient Clinic in aTaipei City Hospital
 
Mei-Hsing Chuang and Chun-Yin Hou^*
 

Purpose: Patients infected with the SARS-CoV-2 may develop symptoms that last for three months,generally referred to as “post-COVID conditions” (PCC). The study aimed to investigate thesymptoms and associated factors of patients with PCC based on the data from a COVID-19integrated outpatient clinic in a Taipei City hospital.
Methods: A retrospective medical record study was conducted to collect patient data from theintegrated COVID-19 clinic from January 2022 to March 2023. The patients were followed up until6 months after the date of release from isolation. PCC was defined as symptoms lasting for 3 months(≥90 days) with no other identifiable cause. A symptom questionnaire completed by each patientwas collected, incorporating the Brief Symptom Rating Scale (BSRS), as well as information ongender, age, history of chronic diseases, COVID-19 vaccination status (receipt of two doses), andhospitalization status during the acute phase.
Results: A total of 174 subjects were enrolled, including 78 males (44.8%) and 96 females (55.2%).PCC was observed in 69 subjects (39.7%), comprising 28 males (40.6%) and 41 females (59.4%).Fatigue, memory loss, cough, attention deficit, headache, muscle aches, and breathing difficultiesemerged as the most common PCC symptoms, and those marked with statistically significantdifferences included memory loss, unexplained hair loss, and skin rashes. Factors significantlyinfluencing the symptoms were gender, gastroesophageal reflux, allergic rhinitis, and hospitalizationduring the acute phase of COVID-19 infection. Among the BSRS items, a significant correlationwas found between the severity of emotional distress and the number of patients experiencing PCC.
Conclusion: COVID-19 infection affects multiple organ systems, and patients may develop a widerange of symptoms. The symptoms of PCC can persist for an extended period, underscoring the needfor long-term follow-up to understand the pathological mechanisms and impacts of COVID-19infection.
(Taiwan J Fam Med 2025; 35: 98-115) DOI: 10.53106/168232812025063502004
 
Key words: Brief Symptom Rating Scale, post acute COVID-19 conditions, SARS-CoV-2,severe acute respiratory syndrome, vaccine
 

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Department of Family Medicine, Taipei City Hospital Zhong-Xiao Branch
Received: July 28, 2024; September 27, 2024; Accepted: December 7, 2024.
^*Corresponding author