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台灣家庭醫學雜誌

個案報告(Case Report)
一位以味覺異常為主訴的維生素B12缺乏個案
維生素B12缺乏、味覺異常、大球性貧血、胃切除
王彤安 、李純瑩*
高雄醫學大學附設中和紀念醫院家庭醫學科1
一位以味覺異常為主訴的維生素B12缺乏個案
 
王彤安 李純瑩*
 
維生素B12缺乏臨床表現多樣,且大多以非特異性症狀表現。對於具風險因子的族群,進行長期追蹤且適度補充維生素B12,能提升病人生活品質。本案例為66歲男性,具有胃癌及全胃切除病史,因味覺異常至家庭醫學科門診就醫,舌背外觀部分區域可見舌乳突扁平及泛紅區塊,經評估診斷為維生素B12缺乏所致的萎縮性舌炎。經補充維生素B12後,臨床症狀顯著改善。期望藉由本案例分享,能夠提升臨床醫師對風險族群維生素B12缺乏診斷之敏感度。
(台灣家醫誌2026; 36: 121-126) DOI: 10.53106/168232812026063602006
 
關鍵詞:維生素B12缺乏、味覺異常、大球性貧血、胃切除

高雄醫學大學附設中和紀念醫院家庭醫學科
受理日期:114年6月3日 修改日期:114年7月7日 同意刊登:114年9月19日
*通訊作者:李純瑩 通訊地址:高雄市三民區自由一路100號 E-mail: june23.lee@gmail.com
 



Vitamin B12 Deficiency Presenting as Dysgeusia:A Case Report
 

Tung-An Wang and Chun-Ying Lee*
 

Vitamin B12 deficiency presents with a wide range of clinical manifestations, most of whichare nonspecific. For high-risk populations, long-term follow-up and appropriate vitamin B12supplementation can improve patients’ quality of life. We report the case of a 66-year-old male witha history of gastric cancer and total gastrectomy who presented to the family medicine outpatientdepartment with dysgeusia. Examination revealed flattened papillae and erythematous patches onpartial areas of the dorsal tongue surface. Upon evaluation, he was diagnosed with atrophic glossitiscaused by vitamin B12 deficiency. After vitamin B12 supplementation, his clinical symptomsimproved significantly. We hope this can will help heighten clinicians’ diagnostic sensitivity tovitamin B12 deficiency in high-risk populations.
(Taiwan J Fam Med 2026; 36: 121-126) DOI: 10.53106/168232812026063602006
 
Key words: dysgeusia, gastrectomy, macrocytic anemia, vitamin B12 deficiency


Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
Received: June 3, 2025; Revised: July 7, 2025; Accepted: September 19, 2025.
*Corresponding author

 
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