Oxford-AstraZeneca COVID-19 疫苗引發的血栓及因應方式
 
林嘉俊¹　江建勰^1,2,3

 
歐洲各國陸續出現在施打牛津阿斯特捷利康新冠肺炎疫苗後出現腦竇靜脈血栓和血小板過低症的案例，此現象已被命名為疫苗誘導的免疫性血栓性血小板過低症。目前發生疫苗誘導的免疫性血栓性血小板過低症的機轉仍未完全確立，且對於亞洲人的風險仍舊不明。本專論探討牛津阿斯特捷利康新冠肺炎疫苗相關之疫苗誘導的免疫性血栓性血小板過低症的流行病學、機轉、診斷標準及治療。
（台灣家醫誌2021; 31: 96-102）DOI: 10.3966/168232812021063102003
 
關鍵詞：牛津新冠肺炎疫苗、腦竇靜脈血栓、疫苗誘導的免疫性血栓性血小板過低症
 

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¹台大醫院家庭醫學部、²台灣大學醫學院家庭醫學科、³台灣大學醫學院藥理學研究所
受理日期：110年4月20日　　修改日期：110年4月30日　　同意刊登：110年5月13日
通訊作者：江建勰　　　　　通訊地址：10048台北市中正區中山南路7號　E-mail：jiansie@ntu.edu.tw

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Oxford-AstraZeneca COVID-19 Vaccine-induced Immune
Thrombotic Thrombocytopenia: What We Need to Know
 
Kar-Chun Lim¹ and Chien-Hsieh Chiang^1,2,3

 
European countries have reported several cases of cerebral sinus vein thrombosis and thrombocytopenia in patients who received the Oxford-AstraZeneca COVID-19 vaccines. This phenomenon is now called vaccine-induced immune thrombotic thrombocytopenia (VITT). The mechanism of VITT and its risks for Asians are still unclear. In this monograph, the epidemiology, mechanism, diagnostic criteria, and treatments of VITT are briefly reviewed.
(Taiwan J Fam Med 2021; 31: 96-102) DOI: 10.3966/168232812021063102003
 
Key words: cerebral sinus vein thrombosis, Oxford-AstraZeneca ChAdOx1 nCoV-19 vaccine, vaccine-induced immune thrombotic thrombocytopenia
 

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¹Department of Family Medicine, National Taiwan University Hospital; ²Department of Family Medicine, National Taiwan University College of Medicine; ³Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan.
Received: April 20, 2021; Revised: April 30, 2020; Accepted: May 13, 2021.