一位八十六歲男性約三個月前注意到肚臍有一約1×1公分紅色堅實微壓痛結節，同時住院前三個禮拜出現漸進式腹脹。肚臍皮膚切片報告顯示其病理特徵為具黏液分泌性轉移腺癌；腹水細胞學檢查發現腺癌細胞，此病人的臨床表現符合Sister Mary Joseph's 結節。Sister Mary Joseph's 結節為肚臍轉移性癌症，可以是腹內惡性腫瘤的臨床徵象；而在過去有癌症病史的病人身上，它是疾病復發的指標。肚臍轉移顯示癌症已產生系統性轉移，而且預後不良。對基層醫師而言，肚臍理學檢查是不可忽視。 　　An 86 year old man has noticed a mild tender, erythematous indurated nodule with the size of 1x1 cm2 on his umbilicus for 3 months. Progressive abdominal distention has been noticed for three weeks before his admission. Skin biopsy of the umbilical lesion revealed an adenocarcinoma with mucin production arranged in glandular structures. Ascites cytology study showed positive for adenocarcinoma. The clinical picture is compatible with the so-called Sister Mary Joseph's nodule. The Sister Mary Joseph's nodule refers as metastatic tumor of the umbilicus. It can often be the first clinical sign of an occult cancer in abdomen or an indicator of recurrence in patients with a known malignant disease. Umbilical metastasis is usually associated with extensive metastatic disease and poor prognosis. For general practitioners, the importance of thorough examination of the umbilicus should not be overlooked.