¹臺北市立聯合醫院陽明院區家庭醫學科
²輔仁大學醫學系
受理日期：114年6月27日 修改日期：114年8月14日 同意刊登：114年9月8日
^*通訊作者：柯澐蓁 通訊地址：臺北市士林區雨聲街105號 E-mail: DXO88@tpech.gov.tw

Amiodarone-Induced Thyroid Dysfunction Presenting asHyperhidrosis: A Case Report
 
Yu-Ching Lo¹ and Yun-Chen Ko^1,2*
 

A 78-year-old male with history of transient ischemic attack visited our cardiovascularoutpatient department due to tachycardia and palpitations. Electrocardiography showed atrialfibrillation (AFib) with rapid ventricular response; amiodarone combined with propranolol was thenprescribed for rhythm and rate control. However, after four weeks of medication, the patientdeveloped excessive sweating and heat intolerance, prompting him to visit our family medicineoutpatient department. He denied any history of thyroid, endocrine or autoimmune disease.Laboratory evaluation revealed hyperthyroidism (TSH: 0.006 μIU/mL, free T4: 1.890 ng/dL), andthyroid sonography showed no abnormality. As amiodarone-induced thyrotoxicosis was suspected,amiodarone was discontinued and replaced with dronedarone. When returning to the clinic twomonths later, the patient reported improvement in sweating but new-onset fatigue. Follow-uplaboratory results indicated hypothyroidism (TSH: 16.000 μIU/mL, free T4: 0.754 ng/dL) and apositive anti-thyroid peroxidase antibody (anti-TPO: 173 IU/mL). Levothyroxine treatment wasprescribed. After seven weeks of treatment, thyroid function normalized with complete resolutionof both sweating and fatigue. normalized with complete resolution of both sweating and fatigue.
(Taiwan J Fam Med 2026; 36: 127-133) DOI: 10.53106/168232812026063602007
 
Key words: amiodarone, thyroid function, sweating

¹Department of Family Medicine, Taipei City Hospital, Yangming Branch
²School of Medicine, Fu Jen Catholic University
Received: June 27, 2025; Revised: August 14, 2025; Accepted: September 8, 2025.
^*Corresponding author