電子期刊
台灣家庭醫學雜誌
蔡斯安1 李知誼1 高宜柔1 陳明皓1 林彥安2,3 陳昭源3,4*
關鍵詞： 人類微小病毒B19型、COVID-19、流行病學
1天主教輔仁大學醫學系
2台北長庚紀念醫院家庭醫學部
3林口長庚紀念醫院家庭醫學部
4長庚大學醫學系
受理日期：114年3月23日 修改日期：114年5月14日 同意刊登：114年5月29日
*通訊作者：陳昭源 通訊地址：桃園市龜山區復興街5號 E-mail：welins@cgmh.org.tw
Resurgence of Human Parvovirus B19 in the Post-COVID-19 Era: Clinical Manifestations, Diagnosis,Management, and Prevention Strategies
Sz-An Tsai1, Zhi-Yi Lee1, Yi-Jou Kao1, Ming-Hao Chen1, Yen-An Lin2,3and Jau-Yuan Chen3,4*
Human parvovirus B19 (B19V) is primarily transmitted through respiratory droplets andclose contact. It commonly causes erythema infectiosum, also known as fifth disease (often calledapple disease in Japan and Taiwan). Most infected individuals experience only mild cold-likesymptoms or remain asymptomatic. However, immunocompromised individuals, patients withhematopoietic disorders, and pregnant women may develop severe complications such as arthritis,aplastic anemia, and hydrops fetalis. Additionally, B19V has been linked to pediatric myocarditis.In the years following the COVID-19 pandemic, several countries—including the UnitedStates, France, Italy, and Israel—have reported an abnormal increase in B19V cases. This resurgencemay be related to immune susceptibility resulting from prolonged social distancing measures. In2024, the European Centre for Disease Prevention and Control reported that since late 2023,infection rates of B19V have risen among pregnant women and blood donors in several Europeancountries, prompting healthcare professionals to heighten awareness of this virus. This studyexplores the clinical manifestations, diagnostic methods, and treatment options of B19V andsummarizes relevant global epidemiological reports and literature to propose preventive strategies.
(Taiwan J Fam Med 2025; 35: 227-235) DOI: 10.53106/168232812025123504002
Key words: COVID-19, epidemiology, human parvovirus B19
1School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan
2Department of Family Medicine, Chang Gung Memorial Hospital, Taipei Branch, Taipei City, Taiwan
3Department of Family Medicine, Chang-Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan
4College of Medicine, Chang-Gung University, Taoyuan, Taiwan
Received: March 23, 2025; Revised: May 14, 2025; Accpted: May 29, 2025.
*Corresponding author