電子期刊
台灣家庭醫學雜誌
高宜柔1 陳昭源2,3 李知誼1 蔡斯安1 陳明皓1 林彥安2,4*
本個案凸顯灼口症的診斷及治療之臨床挑戰性，提醒醫師面對持續性口腔疼痛且無明顯病灶的病人時，需提高對口腔灼熱症的警覺，排除可能的共病症，並透過藥物及非藥物治療的調整，以改善病人的生活品質與治療預後。
(台灣家醫誌2026; 36: 57-68) DOI: 10.53106/168232812026033601006
關鍵詞：灼口症、低能量雷射治療、口腔感覺異常
1天主教輔仁大學醫學系
2林口長庚紀念醫院家庭醫學部
3長庚大學醫學系
4台北長庚紀念醫院家庭醫學部
受理日期：114年3月26日 修改日期：114年5月21日 同意刊登：114年7月7日
*通訊作者：林彥安 通訊地址：桃園市龜山區復興街5號 E-mail：s19401044@gmail.com
Burning Mouth Syndrome: A Case Report with a Review of Current Evidence
Yi-Jou Kao1, Jau-Yuan Chen2,3, Zhi-Yi Lee1, Sz-An Tsai1, Ming-Hao Chen1 and Yen-An Lin2,4*
Burning mouth syndrome (BMS) is a chronic pain disorder characterized by persistent burning, stinging, or abnormal sensations in the oral mucosa, often in the absence of visible clinical lesions. Its etiology remains unclear, although it has been associated with neuropathic changes and psychological factors. The global prevalence is approximately 1.73%, with higher rates noted in women and individuals over 50 years of age. Due to the limited understanding of this condition, BMS is frequently under- or misdiagnosed as other conditions, such as candidiasis or gastroesophageal reflux disease. Although numerous treatment options have been proposed, most lack strong evidence. Management typically requires personalized combination therapy, including anticonvulsants, anxiolytics, antidepressants, and low-level laser therapy.
This article reports a case of a 61-year-old female patient who presented with tongue tip and palatal pain lasting three months, accompanied by severe depressive symptoms. Laboratory tests ruled out other systemic diseases, and the final diagnosis was BMS with concurrent severe depression and candidiasis. Following initial medication combined with low-level laser therapy, her symptoms improved significantly: pain intensity decreased from severe to mild with intermittent episodes, and depressive mood lessened.
This case highlights the clinical challenges in diagnosing and treating BMS, emphasizing the need for physicians to remain vigilant when encountering patients with persistent oral pain without obvious lesions. Identifying potential comorbidities and employing a combination of pharmacological and non-pharmacological therapies can improve treatment outcomes, thereby enhancing the patient's quality of life.
(Taiwan J Fam Med 2026; 36: 57-68) DOI: 10.53106/168232812026033601006
Key words: burning mouth syndrome (BMS), low level laser therapy (LLLT), oral dysesthesia (OD)
*Corresponding author