國人猴痘疫苗接種後之全身和局部反應與心理感受

沈宜萱¹ 張皓翔^2,3 竇巧雲² 李伊真⁴ 李怡萱^2,3程劭儀^2,3 黃國晉^2,3 盧佳文^2,3*
 

Systemic and Local Reactions andPsychological Responses after Monkeypox Vaccinationamong Taiwanese Population

Yi-Hsuan Shen¹, Hao-Hsiang Chang^2,3, Chiao-Yun Tou², Yi-Chen Lee⁴, Yi-Hsuan Lee^2,3,Shao-Yi Cheng^2,3, Kuo-Chin Huang^2,3 and Chia-Wen Lu^2,3*

Aim: A severe outbreak of monkeypox occurred worldwide in 2022, particularly affecting sexualand gender minorities. This study aimed to explore the adverse physical and psychological eventsassociated with different monkeypox vaccination regimens.

Methods: A cross-sectional online survey was conducted from May to June 2023, targeting adultsscheduled for their second dose of pre-exposure prophylaxis vaccine against monkeypox, withparticipants recruited from a medical center in Taiwan. The questionnaire focused on the physicaland psychological impacts of the first monkeypox vaccination, with the preferences of theparticipants for the vaccination regimens of the second vaccination and the factors influencing theirpreferences also inquired.
Results: A total of 2,827 respondents completed the questionnaire. Among physical impacts,common adverse systemic events included fatigue, myalgia, and headache, while common adverselocal events included skin discoloration, erythema, swelling, and itchiness. Intradermal injection inthe forearm was associated with a higher incidence of local adverse reactions, especially skindiscoloration, leading to varying degrees of physical and psychological impacts. “Beauty,” “scar,”and “perceptions of others” emerged to be the most significant factors influencing preferences forvaccination regimens.
Conclusion: This study identified a range of adverse systemic and local reactions associated withdifferent monkeypox vaccination regimens. Understanding the factors influencing preferences forvaccination regimens is crucial for alleviating the physical and psychological stress of vaccinerecipients.