電子期刊
台灣家庭醫學雜誌
原著論文(Original Article)
The Relationship Between Hypertriglyceridemia and Left Ventricular Hypertrophy
高三酸甘油酯血症、左心室肥大、台灣族群、心血管風險因子、cardiovascular risk、hypertriglyceridemia、left ventricular hypertrophy、Taiwanese population
林敬晃1,2†
、許家瑜1†
、張宇辰1
、黃麗卿1,3
、黃偉新1,3
、邵馨慧1
、許馨尹1,3,4*
、鄒孟婷1,5*
馬偕紀念醫院家庭醫學科1
、國立臺灣大學醫學院附設醫院老年醫學部2
、馬偕學校財團法人馬偕醫學院3
、國立臺灣大學流行病學與預防醫學研究所4
、馬偕醫護管理專科學校5
、† 兩人有相等貢獻並列共同第一作者6
、*兩人有相等貢獻並列共同通訊作者7
The Relationship Between Hypertriglyceridemia
and Left Ventricular Hypertrophy
Ching-Huang Lin1,2†, Chia-Yu Hsu1†, Yu-Chen Chang1, Lee-Ching Hwang1,3,
Wei-Hsin Huang1,3, Hsin-Hui Shao1, Hsin-Yin Hsu1,3,4* and Meng-Ting Tsou1,5*
and Left Ventricular Hypertrophy
Ching-Huang Lin1,2†, Chia-Yu Hsu1†, Yu-Chen Chang1, Lee-Ching Hwang1,3,
Wei-Hsin Huang1,3, Hsin-Hui Shao1, Hsin-Yin Hsu1,3,4* and Meng-Ting Tsou1,5*
Background: Left ventricular hypertrophy (LVH), a significant cardiovascular risk, has been associated with lipid profiles, mainly focusing on low-density lipoprotein cholesterol (LDL-C). However, literature on the association between triglycerides (TG) and the risk of LVH is limited and inconsistent. This study investigates the relationship between hypertriglyceridemia and LVH.
Methods: This retrospective study recruited participants from a health center between June 2008 and May 2018, and their information was obtained from hospital records. We divided participants into three groups according to their fasting triglyceride (TG) levels: TG level below 150 mg/dL, between 150-199 mg/dL, and greater or equal to 200 mg/dL. LVH was defined as a left ventricular mass index over 95 g/m2 in women and 115 g/m2 in men, determined by echocardiography. Logistic regression was used to investigate the association between TG levels and LVH. Subgroup analyses were performed to examine whether the association between TG levels and LVH varied by different age and sex groups.
Results: The study included 3,830 participants with a mean age of 52.9 years. The proportion of LVH in the different groups of TG levels was 3.5%, 5.0%, and 6.8%, respectively (test for trend, p< 0.05). Participants with TG levels greater or equal to 200 mg/dL were associated with a higher risk of LVH after adjusting for potential confounding factors [adjusted odds ratio (aOR) 1.57, 95 % confidence interval (CI) 1.04-2.37]. Subgroup analyses revealed consistent results with the main results across different age and sex strata.
Conclusion: Elevated fasting TG levels (≥200 mg/dL) significantly increase LVH risk. Controlling hypertriglyceridemia is vital for reducing cardiovascular risk.
(Taiwan J Fam Med 2023; 33: 193-205) DOI: 10.53106/168232812023123304002
Key words: cardiovascular risk, hypertriglyceridemia, left ventricular hypertrophy, Taiwanese population
1Department of Family Medicine, Taipei MacKay Memorial Hospital, Taipei, Taiwan.
2Department of Geriatrics and Gerontology, National Taiwan University Hospital, Taipei, Taiwan.
3Department of Medicine, Mackay Medical College, New Taipei City, Taiwan.
4Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan.
5MacKay Junior College of Medicine, Nursing, and Management, New Taipei City, Taiwan.
Received: January 23, 2024; Revised: February 27, 2024; Accepted: March 31, 2024.
†These authors contributed equally to this work and shared first authorship.
*These authors contributed equally to this work and share corresponding authorship.
Correspondence: Meng-Ting Tsou and Hsin-Yin Hsu, Department of Family Medicine, Taipei MacKay Memorial Hospital.
Email: mttsou@gmail.com (M-T Tsou); camelhsu@gmail.com (H-Y Hsu)
高三酸甘油酯血症與左心室肥大之相關性研究
林敬晃1,2† 許家瑜1† 張宇辰1 黃麗卿1,3 黃偉新1,3
邵馨慧1 許馨尹1,3,4* 鄒孟婷1,5*
林敬晃1,2† 許家瑜1† 張宇辰1 黃麗卿1,3 黃偉新1,3
邵馨慧1 許馨尹1,3,4* 鄒孟婷1,5*
目的：左心室肥大(left ventricular hypertrophy, LVH)為一重要心血管風險因子，當前研究主要聚焦在低密度脂蛋白膽固醇(low-density lipoprotein cholesterol, LDL-C)，針對與三酸甘油酯(triglyceride, TG)間的關聯討論較少且結果不一致，本篇則旨在探討高三酸甘油酯血症與LVH間關係。
方法：此回顧性研究蒐集自2008年6月至2018年5月間，至北台灣一醫學中心健康檢查的民眾做為參與者。我們根據參與者的空腹血中三酸甘油酯數值將之分為三組：低於150 mg/dL、介於150-199 mg/dL間，以及大於等於200 mg/dL。透過心臟超音波檢查結果，我們定義LVH為女性左心室質量指數超過95 g/m2者，男性為超過115 g/m2者。我們利用多元邏輯迴歸分析觀察TG濃度與LVH之間的關聯，並進行次群組分析以檢驗此關聯在不同年齡和性別群體中是否存在差異。
結果：本篇研究共包含3,830名參加者，平均年齡為52.9歲。各TG濃度組的LVH比例分別為3.5%，5.0%和6.8% (test for trend, p< 0.05)。調整潛在干擾因子後，TG濃度高於200 mg/dL族群的LVH風險較高 [adjusted odds ratio (aOR), 1.57; 95% confidence interval (CI), 1.04-2.37]。次群組分析顯示在不同年齡和性別的分層趨勢皆與主要結果一致。
結論：升高的空腹血中TG濃度(≥200 mg/dL)顯著增加LVH的風險。控制高三酸甘油酯血症對降低心血管風險至關重要。
(台灣家醫誌2023; 33: 193-205) DOI: 10.53106/168232812023123304002
關鍵詞：高三酸甘油酯血症、左心室肥大、台灣族群、心血管風險因子
1馬偕紀念醫院家庭醫學科
2國立臺灣大學醫學院附設醫院老年醫學部
3馬偕學校財團法人馬偕醫學院
4國立臺灣大學流行病學與預防醫學研究所
5馬偕醫護管理專科學校
受理日期：113年1月23日 修改日期：113年2月27日 同意刊登：113年3月31日
†兩人有相等貢獻並列共同第一作者
*兩人有相等貢獻並列共同通訊作者
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